[HTML][HTML] Galectin-3 interacts with the cell-surface glycoprotein CD146 (MCAM, MUC18) and induces secretion of metastasis-promoting cytokines from vascular …
F Colomb, W Wang, D Simpson, M Zafar… - Journal of Biological …, 2017 - ASBMB
The galactoside-binding protein galectin-3 is increasingly recognized as an important player
in cancer development, progression, and metastasis via its interactions with various
galactoside-terminated glycans. We have shown previously that circulating galectin-3, which
is increased up to 30-fold in cancer patients, promotes blood-borne metastasis in an animal
cancer model. This effect is partly attributable to the interaction of galectin-3 with unknown
receptor (s) on vascular endothelial cells and causes endothelial secretion of several …
in cancer development, progression, and metastasis via its interactions with various
galactoside-terminated glycans. We have shown previously that circulating galectin-3, which
is increased up to 30-fold in cancer patients, promotes blood-borne metastasis in an animal
cancer model. This effect is partly attributable to the interaction of galectin-3 with unknown
receptor (s) on vascular endothelial cells and causes endothelial secretion of several …
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